Irreversible Electroporation Ablation Therapy for Pancreatic Adenocarcinoma：Observation of Its Safety and Short-term Effect was published on J Intervent Radiol 2016，V01．25，No．3.This article quotes part of the content to provide a new treatment idea for patients with locally advanced pancreatic cancer that cannot be surgically removed.

According to the research, cardiomyocytes in the ablation area were replaced by fibroblasts and there was no damage outside the ablation zone. Our results show that pulmonary venous isolation using the biphasic asymmetric discharge mode is safe, durable, effective, and causes no damage to other tissues.

Analysis on Efficacy and Safety of Nano-knife Ablation in Treating Advanced Gallbladder Carcinoma was first published on the China National Knowledge Infrastructure (CNKI) website, citing some of the content in order to better inform readers about Nanoknife ablation therapy.

Pulsed Field Ablation (PFA) is a new non-thermal ablation method that works by irreversible electroporation. This method has advantages such as no thermal damage, selective ablation of tissue gradients, and fast speed. Recent studies have shown that PFA has potential advantages in the treatment of atrial fibrillation, but the ablation parameters and underlying mechanisms are not clear. This research is still in the initial stage, and the dose-effect relationship of the major cells (cardiomyocytes and smooth muscle cells) in the ablation process by PFA is not clear. The ablation dose and surgical methods in animal experiments, as well as evaluation indicators, need to be studied. This article conducts preliminary experimental research on the killing effect from two aspects: cytology and large animal experiments. It clarifies the dose-effect relationship and evaluation system of pulsed field ablation, and explores the ablation effect and mechanism of PFA on myocardial tissue through in vivo and in vitro experiments, providing experiment evidence for further clinical trials.

Irreversible electroporation (IRE) technology has gradually gained recognition and favor in clinical practice due to its tissue-selective characteristics and high immunoreactivity. Professor Xiao Yueyong from the Department of Radiology Intervention at the Chinese PLA General Hospital and Director Wang Zhongmin from the Department of Radiology Intervention at the Shanghai Ruijin Hospital have led their teams to make extensive explorations in this field, which is at the forefront of academia. They have convened and published the first edition of the Consensus of Experts on Image-guided Irreversible Electroporation Ablation Therapy for Malignant Liver Tumors, hereafter referred to as the "Consensus."

Irreversible electroporation (IRE) technology uses pulsed waves generated under specific field strength to break the lipid bilayer of tumor cell membranes, forming pores on the cell membrane and disrupting the steady state of large molecules inside and outside the cells, thereby inducing apoptosis. It is a non-thermal tissue-targeted ablation technology, and under the field strength used for tumor treatment, the pulsed waves do not damage important structures such as major blood vessels or the gallbladder, making the treatment more thorough. Here we share a literature titled Safety and efficacy of irreversible electroporation ablation in treating liver cancer, authored by Dr. Chen Guang and Professor Wang Hao's team from the Department of Radiology and Interventional at Tianjin First Central Hospital, which took three years to write and was published in the issue two of 28th of the 2022 Chinese Journal of Hepatobiliary Surgery. The equipment used was the High Voltage Steep Pulse Minimally Invasive Therapeutic System independently developed by Alpmed.