On November 1, 2022, Dr. Zhang Fan's team from the Pancreatic Surgery Department of Binzhou Medical University Affiliated Hospital successfully carried out and completed an additional surgery for pancreatic tumors with the help of the High Voltage Pulse Minimally Invasive Therapeutic System independently developed and produced by Alpmed.

The patient is a 35-year-old male who was admitted to the hospital about 15 days ago due to obvious abdominal distension and intermittent abdominal pain. The CT scan of the upper abdomen showed that the pancreas was relatively full, and there was a suspicious soft tissue density shadow in the pancreatic neck area, accompanied by mild dilation of the distal main pancreatic duct. Combined with the medical history, the diagnosis was "occupying lesion of the pancreas", and after further examination, it was diagnosed as pancreatic cancer. 

Due to the special location of the tumor, which was located at the pancreatic neck and had a maximum diameter of 4cm, conventional surgery posed a great risk. Dr. Zhang Fan's team from the Pancreatic Surgery Department of Binzhou Medical University Affiliated Hospital decided to perform a Nanoknife ablation surgery to remove the tumor for the patient. The Nanoknife ablation surgery can accurately ablate the tumor without damaging the pancreatic duct and surrounding large blood vessels, and has a high success rate with almost no adverse reactions after surgery.

This surgery was personally performed by Director Zhang Fan, using the diamond-shaped needle placement method. The four needles were parallel to each other, with the tip of the ablation needle exposed 1cm and a distance of 1.5-2cm between each needle, ensuring complete coverage of the tumor before performing pancreatic tumor ablation. The first group had a voltage of 2800V, and the real-time synchronized monitoring of the Ailuoyi steep pulse minimally invasive treatment system showed that the current steadily increased from 25A to 35A, with good ablation effect and a duration of 8 minutes. The second group had the ablation needle retracted by 1cm, and the current increased from 35A to 45A, with good ablation effect and a duration of 8 minutes. The last group had the needle retracted by another 1cm, and the voltage was lowered to 2500V. The current increased from 35A to 47A, and the tumor was completely eliminated in 8 minutes. The equipment used in the surgery, the Ailuoyi steep pulse minimally invasive treatment system, maintained high voltage throughout the surgery with almost no attenuation, ensuring the smooth progress of the surgery. Finally, Director Zhang Fan completed the needle retraction, and the surgery was successful. After the surgery, combined treatment was given, and the patient's various signs recovered well. After a comprehensive re-examination, no obvious abnormal conditions were found.

（One week postoperative MRI）

Director Zhang Fan stated that the Ailray DPC micro-invasive treatment system provided assurance for the smooth progress of surgery, and the stable energy field and electrocardiogram synchronous detection function filled the gap in the European and American markets for Nanoknife ablation devices. It is hoped that Nanoknife ablation surgery can be more quickly promoted for clinical use in the treatment of tumors, benefiting more patients.

The First Medical Center of the General Hospital of the Chinese People's Liberation Army (PLA), led by Prof. Xiao Yueyong, has established the First Medical Center of the PLA General Hospital as the main research unit for the ablation treatment of pancreatic malignant tumors with the Steep Pulse Therapy Instrument (Nano Knife), and the Affiliated Hospital of Binzhou Medical College as the first sub-center!

Binzhou Medical College Hospital was recognized as a tertiary hospital in May 1995, becoming the youngest tertiary general hospital in the country in the first round of review, becoming one of the first seven provincial-level regional medical centers in Shandong Province in December 2015, and the hospital passed a new round of hospital grade review with excellent results in December 2021. Since the establishment of the hospital, it has insisted on medical treatment, teaching and scientific research, and achieved good and rapid development in all undertakings, firmly establishing its status as a medical, teaching, scientific research, rehabilitation and emergency center in the Yellow River Delta region.

With the rapid development of various diagnostic techniques and interventional treatments, the use of NanoKnife will become more and more widespread, providing a new treatment option for patients with locally progressive pancreatic cancer that cannot be surgically resected or is difficult and risky to resect.

Now Binzhou Hospital is recruiting pancreatic cancer patients. For details of recruitment requirements and how to apply, please click the article link below.

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【Patient Recruitment】 Pancreatic Cancer NanoKnife Ablation Clinical Trial