In the afternoon of January 11, 2022, the first ultrasound interventional nano-knife treatment for liver malignancy was successfully completed. The team of Prof. Wang Hui from the Ultrasound Department of Sino-Japanese Friendship Hospital of Jilin University (JJUH) was responsible for this treatment.During the therapy, High Voltage Steep Pulse Minimally Invasive Therapeutic Apparatus was used, which was developed and manufactured by Shanghai Yuanshan Medical Technology Co.,Ltd(Alpmed).The tumor ablation surgery was successfully completed for a 64-year-old liver cancer patient through ultrasound-guided puncture.